A new function in translocation for the mitochondrial i-AAA protease Yme1: import of polynucleotide phosphorylase into the intermembrane space.

@article{Rainey2006ANF,
  title={A new function in translocation for the mitochondrial i-AAA protease Yme1: import of polynucleotide phosphorylase into the intermembrane space.},
  author={Robert N Rainey and Jenny D Glavin and Hsiao-Wen Chen and Samuel William French and Michael A Teitell and Carla M Koehler},
  journal={Molecular and cellular biology},
  year={2006},
  volume={26 22},
  pages={8488-97}
}
Polynucleotide phosphorylase (PNPase) is an exoribonuclease and poly(A) polymerase postulated to function in the cytosol and mitochondrial matrix. Prior overexpression studies resulted in PNPase localization to both the cytosol and mitochondria, concurrent with cytosolic RNA degradation and pleiotropic cellular effects, including growth inhibition and apoptosis, that may not reflect a physiologic role for endogenous PNPase. We therefore conducted a mechanistic study of PNPase biogenesis in the… CONTINUE READING
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