A new function for nonsense-mediated mRNA-decay factors.

  title={A new function for nonsense-mediated mRNA-decay factors.},
  author={Miles F. Wilkinson},
  journal={Trends in genetics : TIG},
  volume={21 3},
mRNAs often contain premature-termination (nonsense) codons as a result of mutations and RNA splicing errors. These nonsense codons cause rapid decay of the mRNAs that contain them, a phenomenon called nonsense-mediated mRNA decay (NMD). This response is thought to be a quality-control mechanism that protects cells from truncated dominant-negative proteins. Surprisingly, recent evidence strongly suggests that the NMD factors UPF1, UPF2, UPF3B, RNPS1, Y14 and MAGOH also promote translation of… CONTINUE READING


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