A new function for a common fold: the crystal structure of quinolinic acid phosphoribosyltransferase.

@article{Eads1997ANF,
  title={A new function for a common fold: the crystal structure of quinolinic acid phosphoribosyltransferase.},
  author={Jonathan Eads and Durmus Ozturk and Thomas B. Wexler and Charles Grubmeyer and James C. Sacchettini},
  journal={Structure},
  year={1997},
  volume={5 1},
  pages={47-58}
}
BACKGROUND Quinolinic acid (QA) is a neurotoxin and has been shown to be present at high levels in the central nervous system of patients with certain diseases, such as AIDS and meningitis. The enzyme quinolinic acid phosphoribosyltransferase (QAPRTase) provides the only route for QA metabolism and is also an essential step in de novo NAD biosynthesis. QAPRTase catalyzes the synthesis of nicotinic acid mononucleotide (NAMN) from QA and 5-phosphoribosyl-1-pyrophosphate (PRPP). The structures of… CONTINUE READING