A new form of amyloid protein associated with chronic hemodialysis was identified as beta 2-microglobulin.

@article{Gejyo1985ANF,
  title={A new form of amyloid protein associated with chronic hemodialysis was identified as beta 2-microglobulin.},
  author={Fumitake Gejyo and Tsuyoshi Yamada and Shoji Odani and Yuzo Nakagawa and Masayuki Arakawa and Tetsunosuke Kunitomo and Hiroshi Kataoka and Minoru Suzuki and Yoshihei Hirasawa and Tsuranobu Shirahama},
  journal={Biochemical and biophysical research communications},
  year={1985},
  volume={129 3},
  pages={701-6}
}
Amyloid fibrils were isolated from amyloid-laden tissue obtained from a chronic hemodialysis patient with carpal tunnel syndrome. After solubilization in guanidine HCl, a significant amount of the protein was located in a homogeneous low molecular weight fraction. The protein was found to be identical to beta 2-microglobulin, with regard to its molecular weight of 11,000, amino acid composition and 16 amino-terminal amino acids: Ile-Gln-Arg-Thr-Pro-Lys-Ile-Gln-Val-Tyr-Ser-Arg-His-Pro-Ala-Glu… CONTINUE READING
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