A new form of Filgrastim with sustained duration in vivo and enhanced ability to mobilize PBPC in both mice and humans.

@article{Molineux1999ANF,
  title={A new form of Filgrastim with sustained duration in vivo and enhanced ability to mobilize PBPC in both mice and humans.},
  author={Graham Molineux and Olaf B. Kinstler and Brian L. Briddell and Cynthia Hartley and Patricia A. McElroy and Patrick J. Kerzic and Weston Sutherland and Gerald Stoney and Brent Kern and Fred A. Fletcher and Amos M. Cohen and Ephraim Korach and Tom Ulich and I K Mcniece and Pamela Lockbaum and Mary Ann Miller-Messana and Sandra J. Gardner and Toby Hunt and Gisela G. Schwab},
  journal={Experimental hematology},
  year={1999},
  volume={27 12},
  pages={
          1724-34
        }
}
Granulocyte colony-stimulating factor (G-CSF) has proven effective in the prophylaxis of chemotherapy-induced neutropenia and as a mobilizer of peripheral blood progenitor cells. The longevity of G-CSF action is limited by its removal from the body by two mechanisms. The first is thought to be mediated via receptors (receptor mediated clearance [RMC]) predominantly on neutrophils, the second process is likely the result of renal clearance. With the intention of developing a novel form of… CONTINUE READING
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