A new flavone sulfonic acid from Phyllanthus urinaria

  title={A new flavone sulfonic acid from Phyllanthus urinaria},
  author={Nguy{\^e}̃n Văn Thành and Phan Thị Thanh Hương and Nguyen Hoai Nam and Nguyễn Xu{\^a}n Cường and Nguyen Phuong Thao and Bieke Dejaegher and Andr{\'e}a Y Gordien and Yvan Vander Heyden and Jo{\"e}lle Quetin-Leclercq and Ch{\^a}u Văn Minh},
One new flavone derivative, urinariaflavone (1), and eight known compounds (2–9) were isolated from the methanolic extract of Phyllanthus urinaria L. leaves. Their structures were established by MS, 1D and 2D NMR experiments, and comparison with literature data. All isolated compounds were tested for their cytotoxic activity against CHO (Chinese hamster ovary) and J774 (Murine macrophage) cell lines. Cytotoxic effects (IC50s ∼ 6.00–41.30 μM) on both cell lines were observed for compounds 4, 5… CONTINUE READING