A new family of insect tyramine receptors.

@article{Cazzamali2005ANF,
  title={A new family of insect tyramine receptors.},
  author={Giuseppe Cazzamali and Dan Arne Klaerke and Cornelis J P Grimmelikhuijzen},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={338 2},
  pages={
          1189-96
        }
}
The Drosophila Genome Project database contains a gene, CG7431, annotated to be an "unclassifiable biogenic amine receptor." We have cloned this gene and expressed it in Chinese hamster ovary cells. After testing various ligands for G protein-coupled receptors, we found that the receptor was specifically activated by tyramine (EC(50), 5x10(-7)M) and that it showed no cross-reactivity with beta-phenylethylamine, octopamine, dopa, dopamine, adrenaline, noradrenaline, tryptamine, serotonin… Expand
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