A new family of growth factors produced by the fat body and active on Drosophila imaginal disc cells.

@article{Kawamura1999ANF,
  title={A new family of growth factors produced by the fat body and active on Drosophila imaginal disc cells.},
  author={Katsumi Kawamura and Toshikatsu Shibata and Olivier Saget and D. R. Peel and Peter J. Bryant},
  journal={Development},
  year={1999},
  volume={126 2},
  pages={211-9}
}
By fractionating conditioned medium (CM) from Drosophila imaginal disc cell cultures, we have identified a family of Imaginal Disc Growth Factors (IDGFs), which are the first polypeptide growth factors to be reported from invertebrates. The active fraction from CM, as well as recombinant IDGFs, cooperate with insulin to stimulate the proliferation, polarization and motility of imaginal disc cells. The IDGF family in Drosophila includes at least five members, three of which are encoded by three… CONTINUE READING
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by decapentaplegic

  • G. H. Renkema, R. G. Boot, +5 authors J. M. Aerts
  • 1998
1 Excerpt

Drosophila cells in culture

  • G. Echalier
  • San Diego: Academic Press.
  • 1997
2 Excerpts

territories created by mutual antagonism between Wingless and Decapentaplegic

  • G. F. Verheijden, A. W. Rijnders, +8 authors A. M. Boots
  • Developmental
  • 1997
1 Excerpt

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