A new family of G-protein regulators - the RGS proteins.

  title={A new family of G-protein regulators - the RGS proteins.},
  author={Michael R Koelle},
  journal={Current opinion in cell biology},
  volume={9 2},
Genetic experiments have recently been used to identify a family of 'regulator of G-protein signaling' (RGS) proteins, which downregulate signaling by heterotrimeric G proteins. The first biochemical studies of RGS proteins have shown that they accelerate the GTPase activities of G-protein alpha subunits, thus driving G proteins into their inactive GDP-bound forms. The physiological significance of the large number of different RGS proteins remains to be explored. 

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