A new facile synthetic route to [11C]GSK189254, a selective PET radioligand for imaging of CNS histamine H3 receptor.

Abstract

GSK189254 and its corresponding precursor GSK185071B were synthesized from 3-methoxyphenylacetic acid with 6-chloropyridine-3-carbolic acid or 6-chloronicotinamide in 8 and 7 steps with either 6% or 7% and either 14% or 16% yield, respectively. [(11)C]GSK189254 was prepared from GSK185071B with [(11)C]CH(3)OTf through N-[(11)C]methylation and isolated by… (More)
DOI: 10.1016/j.bmcl.2012.05.076

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Cite this paper

@article{Wang2012ANF, title={A new facile synthetic route to [11C]GSK189254, a selective PET radioligand for imaging of CNS histamine H3 receptor.}, author={Min Wang and Mingzhang Gao and Brandon L Steele and Barbara E Glick-Wilson and Clive Brown-Proctor and A. Chandra Shekhar and Gary D. Hutchins and Qi-Huang Zheng}, journal={Bioorganic & medicinal chemistry letters}, year={2012}, volume={22 14}, pages={4713-8} }