A new extended-release niacin (Niaspan): efficacy, tolerability, and safety in hypercholesterolemic patients.

@article{Morgan1998ANE,
  title={A new extended-release niacin (Niaspan): efficacy, tolerability, and safety in hypercholesterolemic patients.},
  author={John M. Morgan and David M. Capuzzi and John R. Guyton},
  journal={The American journal of cardiology},
  year={1998},
  volume={82 12A},
  pages={
          29U-34U;  discussion 39U-41U
        }
}
Immediate-release niacin manifests beneficial effects in cardiovascular disease with respect to dyslipidemic states. It lowers low-density lipoprotein (LDL) cholesterol, triglycerides, lipoprotein(a), and apoprotein B; at the same time, it increases high-density lipoprotein (HDL) cholesterol, HDL2, and apoprotein A-I. However, use of crystalline niacin has drawbacks: therapy requires multidose regimens, and side effects include flushing and pruritus. Slowing absorption with sustained-release… CONTINUE READING

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