A new experimental metastasis model in athymic nude mice, the human malignant melanoma LOX.

@article{Fodstad1988ANE,
  title={A new experimental metastasis model in athymic nude mice, the human malignant melanoma LOX.},
  author={Oystein Fodstad and Steinar Aamdal and Malgorzata McMenamin and Jahn Marthin Nesland and Alexander Pihl},
  journal={International journal of cancer},
  year={1988},
  volume={41 3},
  pages={442-9}
}
The human tumor line LOX was established as an s.c. xenograft in nude mice from a lymph-node metastasis of a patient with malignant melanoma. I.v. injection into adult nude mice of single-cell suspensions prepared from xenografts resulted in progressively growing lung tumor colonies that killed the animals. No difference in colony formation was seen between cells taken from lung colonies and s.c. xenografts. An in vitro cell line, LOX-L, was established from lung colonies, and the monolayer… CONTINUE READING