A new experimental animal model of portal hypertension. Intrahepatic portal obstruction by injecting DEAE-cross-linked dextran microspheres into the portal vein in the rabbit.

Abstract

We proposed a new experimental animal model for portal hypertension in the female Japanese white rabbit by an intraportal injection of DEAE-cross-linked dextran microspheres (100 +/- 25 microns in diameter). Histology of the liver revealed portal obstruction by the injected microspheres in almost all portal triads, resulting in a foreign body granuloma. A… (More)

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