A new dynamic index of insulin sensitivity

  title={A new dynamic index of insulin sensitivity},
  author={Gianluigi Pillonetto and Andrea Caumo and Giovanni Sparacino and Claudio Cobelli},
  journal={IEEE Transactions on Biomedical Engineering},
Insulin sensitivity is a crucial parameter of glucose metabolism. The standard measures of insulin sensitivity obtained by an euglycaemic hyperinsulinaemic clamp, S/sub I/(clamp), or by the minimal model (MM), S/sub I/, do not account for the dynamics of insulin action, i.e., how fast or slow insulin action reaches its plateau value. This is an important physiological information. In this paper we formally define a new insulin sensitivity index which also incorporates information on the… CONTINUE READING
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