A new dual inhibitor of arachidonate metabolism isolated from Helichrysum italicum.

@article{Sala2003AND,
  title={A new dual inhibitor of arachidonate metabolism isolated from Helichrysum italicum.},
  author={Araceli Sala and M Carmen Recio and Guillermo Schinella and Salvador M{\'a}{\~n}ez and Rosa Marfa Giner and J V Rios},
  journal={European journal of pharmacology},
  year={2003},
  volume={460 2-3},
  pages={219-26}
}
Six acetophenones (1-6) and one gamma-pyrone (7), previously isolated from Helichrysum italicum, were tested for their ability to inhibit enzymatic and non-enzymatic lipid peroxidation, the stable 1,1-diphenyl-2-pycryl-hydrazyl free radical, superoxide scavenging and arachidonic acid metabolism. In addition, they were studied in different experimental models such as the chronic inflammation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA), the phospholipase A(2)-induced mouse paw oedema… CONTINUE READING