A new diterpenoid with antispasmodic activity from Salvia cinnabarina.

  title={A new diterpenoid with antispasmodic activity from Salvia cinnabarina.},
  author={Giovanni Romussi and G Ciarallo and Angela Bisio and Nunzia Fontana and Francesco De Simone and Nunziatina De Tommasi and Nicola Mascolo and Luisa Pinto},
  journal={Planta medica},
  volume={67 2},
From the leaf surface exudate of the aerial parts of Salvia cinnabarina a new secoisopimarane diterpenoid with a non-specific spasmolytic activity on histamine-, acetylcholine-, and barium chloride-induced contractions in the isolated guinea-pig ileum was obtained. The IC50 value obtained was comparable with that obtained for papaverine. The structure of 3,4-secoisopimara-4(18),7,15-triene-3-oic acid was established by 1D and 2D NMR spectroscopic techniques. 

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