A new development of triterpene acid-containing extracts from Viscum album L. displays synergistic induction of apoptosis in acute lymphoblastic leukaemia.

@article{Delebinski2012AND,
  title={A new development of triterpene acid-containing extracts from Viscum album L. displays synergistic induction of apoptosis in acute lymphoblastic leukaemia.},
  author={Catharina I Delebinski and Sebastian Jaeger and K Kemnitz-Hassanin and G{\"u}nter H R Henze and Holger N Lode and Georg J. Seifert},
  journal={Cell proliferation},
  year={2012},
  volume={45 2},
  pages={176-87}
}
OBJECTIVES Aqueous Viscum album L. extracts are widely used for anti-cancer therapies. Due to their low solubility, triterpenes (which are known to act on cancers), do not occur in aqueous extracts in significant amounts. Using cyclodextrins, we have found it possible to solubilize mistletoe triterpene acids and to determine their effects on acute lymphoblastic leukaemia (ALL) in vitro and in vivo. MATERIALS AND METHODS A C.B-17/SCID model of pre-B ALL (NALM-6) was used to test efficacy and… CONTINUE READING
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