A new design of knife edged-AFM probe for chromosome precision manipulating

  title={A new design of knife edged-AFM probe for chromosome precision manipulating},
  author={Mitsutoshi Saito and Kenji Nakagawa and Keiichiro Yamanaka and Yuzuru Takamura and Gen Hashiguchi and Eiichi Tamiya},
  journal={The 13th International Conference on Solid-State Sensors, Actuators and Microsystems, 2005. Digest of Technical Papers. TRANSDUCERS '05.},
  pages={155-158 Vol. 1}
We have studied a new approach to analyzing the genetic information and manipulating the three dimensional structure of human chromosomes by atomic force microscopy (AFM). A novel knife edge-shaped AFM probe device has been designed and fabricated on the basis of micromachining technology for the manipulation of double-stranded DNA and human chromosomes. We attempted to dissect double-stranded DNA and human chromosomes physically using the knife-edged probe under AFM operation. It was possible… CONTINUE READING


Publications citing this paper.


Publications referenced by this paper.
Showing 1-9 of 9 references

Proteome analysis of human metaphase chromosomes,

  • Hori, T. Higashi, +6 authors K. Fukui
  • J. B id . Chem.,
  • 2005

Atomic force microscopy imaging and pulling of nucleic acids

  • L. Zhou
  • Cum Opin . S ~ TZICI . Bid .
  • 2004

Nanofabrication with atomic force microscopy

  • T. Mori Iwabuchii, K. Ogawa, K. Sato. M. Saito, Y. Morita, T Ushiki, E. Tamiya
  • J . Nanosci . Nunotechnol .
  • 2004

Application of a microchamber array for DNA amplification using a novel dispensing method

  • S. Kobayashi S. Uchiyama, H. Takata, +9 authors K. Fukui
  • Arch . Hisfol . Cyfol .
  • 2002

Scanning probe evolution in biology,

  • T. A. Brown
  • BIOS Scientific Publishers Ltd., Oxford,
  • 2002

Atomic force microscope - based dissection of human metaphase chromosomes and high resolutional imaging by carbon nanotube tip

  • K. Keman Y. Matsubara, M. Kobayashi, S. Yamamura, Y. Motita, E. Tamiya
  • Arch . Histol . Cvtol . .

Similar Papers

Loading similar papers…