A new design of knife edged-AFM probe for chromosome precision manipulating

@article{Saito2005AND,
  title={A new design of knife edged-AFM probe for chromosome precision manipulating},
  author={Mitsutoshi Saito and Kenji Nakagawa and Keiichiro Yamanaka and Yuzuru Takamura and Gen Hashiguchi and Eiichi Tamiya},
  journal={The 13th International Conference on Solid-State Sensors, Actuators and Microsystems, 2005. Digest of Technical Papers. TRANSDUCERS '05.},
  year={2005},
  volume={1},
  pages={155-158 Vol. 1}
}
We have studied a new approach to analyzing the genetic information and manipulating the three dimensional structure of human chromosomes by atomic force microscopy (AFM). A novel knife edge-shaped AFM probe device has been designed and fabricated on the basis of micromachining technology for the manipulation of double-stranded DNA and human chromosomes. We attempted to dissect double-stranded DNA and human chromosomes physically using the knife-edged probe under AFM operation. It was possible… CONTINUE READING

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