A new dawn for androgens: Novel lessons from 11-oxygenated C19 steroids

  title={A new dawn for androgens: Novel lessons from 11-oxygenated C19 steroids},
  author={E. Pretorius and W. Arlt and K. Storbeck},
  journal={Molecular and Cellular Endocrinology},
  • E. Pretorius, W. Arlt, K. Storbeck
  • Published 2017
  • Biology, Medicine
  • Molecular and Cellular Endocrinology
  • The abundant adrenal C19 steroid 11β-hydroxyandrostenedione (11OHA4) has been written off as a dead-end product of adrenal steroidogenesis. However, recent evidence has demonstrated that 11OHA4 is the precursor to the potent androgenic 11-oxygenated steroids, 11-ketotestosterone and 11-ketodihydrotestosterone, that bind and activate the human androgen receptor similarly to testosterone and DHT. The significance of this discovery becomes apparent when considering androgen dependent diseases such… CONTINUE READING
    64 Citations
    11-Oxygenated C19 Steroids Are the Predominant Androgens in Polycystic Ovary Syndrome
    • 95
    • PDF
    Canonical and Noncanonical Androgen Metabolism and Activity.
    • 1
    Intracrine androgen biosynthesis, metabolism and action revisited
    • 53
    The role of adrenal derived androgens in castration resistant prostate cancer
    • 5
    Monogenic Disorders of Adrenal Steroidogenesis
    • 9
    • PDF


    Adrenal-derived 11-oxygenated 19-carbon steroids are the dominant androgens in classic 21-hydroxylase deficiency.
    • 89
    • Highly Influential
    • PDF
    The 5α-Androstanedione Pathway to Dihydrotestosterone in Castration-Resistant Prostate Cancer
    • N. Sharifi
    • Biology, Medicine
    • Journal of Investigative Medicine
    • 2012
    • 35
    Biological Activity of 9α-Fluoro-llβ-Hydroxy-Δ4-Androstene-3,17-Dione.∗ †
    • 10
    The influence of Aspalathus linearis (Rooibos) and dihydrochalcones on adrenal steroidogenesis: Quantification of steroid intermediates and end products in H295R cells
    • 80
    Inactivation of androgens by UDP-glucuronosyltransferase enzymes in humans
    • 214
    The backdoor pathway to dihydrotestosterone
    • R. Auchus
    • Biology, Medicine
    • Trends in Endocrinology & Metabolism
    • 2004
    • 284
    • Highly Influential
    Dissecting human adrenal androgen production
    • 238
    • Highly Influential