A new dawn for androgens: Novel lessons from 11-oxygenated C19 steroids

@article{Pretorius2017AND,
  title={A new dawn for androgens: Novel lessons from 11-oxygenated C19 steroids},
  author={E. Pretorius and W. Arlt and K. Storbeck},
  journal={Molecular and Cellular Endocrinology},
  year={2017},
  volume={441},
  pages={76-85}
}
  • E. Pretorius, W. Arlt, K. Storbeck
  • Published 2017
  • Biology, Medicine
  • Molecular and Cellular Endocrinology
  • The abundant adrenal C19 steroid 11β-hydroxyandrostenedione (11OHA4) has been written off as a dead-end product of adrenal steroidogenesis. However, recent evidence has demonstrated that 11OHA4 is the precursor to the potent androgenic 11-oxygenated steroids, 11-ketotestosterone and 11-ketodihydrotestosterone, that bind and activate the human androgen receptor similarly to testosterone and DHT. The significance of this discovery becomes apparent when considering androgen dependent diseases such… CONTINUE READING
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    References

    SHOWING 1-10 OF 140 REFERENCES
    Adrenal-derived 11-oxygenated 19-carbon steroids are the dominant androgens in classic 21-hydroxylase deficiency.
    • 89
    • Highly Influential
    • PDF
    The 5α-Androstanedione Pathway to Dihydrotestosterone in Castration-Resistant Prostate Cancer
    • N. Sharifi
    • Biology, Medicine
    • Journal of Investigative Medicine
    • 2012
    • 35
    Biological Activity of 9α-Fluoro-llβ-Hydroxy-Δ4-Androstene-3,17-Dione.∗ †
    • 10
    The influence of Aspalathus linearis (Rooibos) and dihydrochalcones on adrenal steroidogenesis: Quantification of steroid intermediates and end products in H295R cells
    • 80
    Inactivation of androgens by UDP-glucuronosyltransferase enzymes in humans
    • 214
    The backdoor pathway to dihydrotestosterone
    • R. Auchus
    • Biology, Medicine
    • Trends in Endocrinology & Metabolism
    • 2004
    • 284
    • Highly Influential
    Dissecting human adrenal androgen production
    • 238
    • Highly Influential