A new concept in the pharmacology of neuroprotection

  title={A new concept in the pharmacology of neuroprotection},
  author={Illana Gozes and Douglas E. Brenneman},
  journal={Journal of Molecular Neuroscience},
Vasoactive intestinal peptide (VIP), originally discovered in the intestine as a peptide of 28 amino acids, was later found to be a major brain peptide having neuroprotective activities. To exert neuroprotective activity, VIP requires glial cells secreting neuroprotective proteins. Activity-dependent neurotrophic factor (ADNF) is a recently isolated factor secreted by glial cells under the action of VIP. This protein, isolated by sequential chromatographic methods, was named activity-dependent… CONTINUE READING


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