A new concept in the pharmacology of neuroprotection

@article{Gozes2000ANC,
  title={A new concept in the pharmacology of neuroprotection},
  author={Illana Gozes and Douglas E. Brenneman},
  journal={Journal of Molecular Neuroscience},
  year={2000},
  volume={14},
  pages={61-68}
}
Vasoactive intestinal peptide (VIP), originally discovered in the intestine as a peptide of 28 amino acids, was later found to be a major brain peptide having neuroprotective activities. To exert neuroprotective activity, VIP requires glial cells secreting neuroprotective proteins. Activity-dependent neurotrophic factor (ADNF) is a recently isolated factor secreted by glial cells under the action of VIP. This protein, isolated by sequential chromatographic methods, was named activity-dependent… CONTINUE READING

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References

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Showing 1-10 of 39 references

Mapping the active site in vasoactive intestinal peptide to a core of four amino acids: neuroprotective drug design.

Proceedings of the National Academy of Sciences of the United States of America • 1999
View 3 Excerpts

Glial cell

K. Krieglstein, P. Henheik, +4 authors K. Unsicker
1998
View 1 Excerpt

Interna - tional Union of Pharmacology XVIII . Nomenclature of receptors for vasoactive intestinal peptide ( VIP ) and pituitary adenylate cyclase activating polypeptide ( PACAP )

J. HarmarA., A. Arimura, +3 authors R. PisegnaJ.
Pharmacol . Rev . • 1998

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