A new concept in (adenoviral) oncogenesis: integration of foreign DNA and its consequences.

@article{Doerfler1996ANC,
  title={A new concept in (adenoviral) oncogenesis: integration of foreign DNA and its consequences.},
  author={Walter Doerfler},
  journal={Biochimica et biophysica acta},
  year={1996},
  volume={1288 2},
  pages={F79-99}
}
A new concept for viral oncogenesis is presented which is based on experimental work on the chromosomal integration of adenovirus DNA into mammalian genomes. The mechanism of adenovirus DNA integration is akin to non-sequence-specific insertional recombination in which patch homologies between the recombination partners are frequently observed. This reaction has been imitated in a cell-free system by using nuclear extracts from hamster cells and partly purified fractions derived from them. As a… CONTINUE READING