# A new computational paradigm in multiscale simulations: Application to brain blood flow

@article{Grinberg2011ANC, title={A new computational paradigm in multiscale simulations: Application to brain blood flow}, author={Leopold Grinberg and Joseph A. Insley and Vitali A. Morozov and Michael E. Papka and George Em Karniadakis and Dmitry A. Fedosov and Kalyan Kumaran}, journal={2011 International Conference for High Performance Computing, Networking, Storage and Analysis (SC)}, year={2011}, pages={1-12} }

Interfacing atomistic-based with continuum-based simulation codes is now required in many multiscale physical and biological systems. We present the computational advances that have enabled the first multiscale simulation on 190,740 processors by coupling a high-order (spectral element) Navier-Stokes solver with a stochastic (coarse-grained) Molecular Dynamics solver based on Dissipative Particle Dynamics (DPD). The key contributions are proper interface conditions for overlapped domains…

## 40 Citations

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A multi-physics adaptive window algorithm, in which individual red blood cells are explicitly modeled in a small region of interest moving through a coupled arterial fluid domain, that scales efficiently on heterogeneous architectures and enables us to perform large, highly-resolved particle-tracking simulations that would otherwise be intractable.

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This work focuses on the review of particle-based multiscale and hybrid methods that have surfaced in the field of fluid mechanics over the last 20 years. We consider five established particle…

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