A new comprehensive gene expression panel to study tumor micrometastasis in patients with high-risk breast cancer.

@article{Ferrucci2007ANC,
  title={A new comprehensive gene expression panel to study tumor micrometastasis in patients with high-risk breast cancer.},
  author={Pier Francesco Ferrucci and Cristina Rabascio and Federica Gigli and Chiara Antonia Corsini and Giulio Giordano and Francesco Bertolini and Giovanni Martinelli},
  journal={International journal of oncology},
  year={2007},
  volume={30 4},
  pages={955-62}
}
The incidence and prognostic relevance of bone marrow (BM) and leukapheresis (PBPC) tumor cell contamination (TCC) in breast cancer patients is still to be circumstantiated. We developed a new comprehensive gene expression panel to study cytokeratins (CK), maspin (MAS) and mammaglobin (MAM) as possible predictors of prognosis. Forty-eight patients undergoing high dose chemotherapy (HDCT) and PBPC support were enrolled and analyzed for TCC on 116 PBPC apheresis and 96 BM obtained at basal… CONTINUE READING