A new complement function: solubilization of antigen-antibody aggregates.

  title={A new complement function: solubilization of antigen-antibody aggregates.},
  author={Gary W. Miller and Victor Nussenzweig},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={72 2},
Antigen-antibody aggregates are solubilized when incubated with fresh serum at 37 degrees, yielding immune-complexes of relatively small molecular weight which contain antigen, antibody, and complement (C3)determinants. Solubilization is complement-dependent,requires free Mg++ but not Ca++, and proceeds in sera from C4- or C5-deficient animals. It is accelerated in the presence of Ca++ in normal or C4-deficient guinea pig serum, suggesting involvement of the Cl-bypass activation of the… CONTINUE READING
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