A new classification for HIV-1

  title={A new classification for HIV-1},
  author={Edward A Berger and Robert W. Doms and Eva Maria Fenyö and Bt Korber and Dan R. Littman and J. Peter Moore and Quentin J. Sattentau and Hanneke Schuitemaker and Joseph G. Sodroski and Robin A. Weiss},
The phenotype of HIV-1 isolates is defined by the cells in which they replicate in vitro, but these phenotypes can change in vivo with profound implications for viral transmission, pathogenesis and disease progression. Here we propose a new classification system based on co-receptor use, providing a more accurate description of viral phenotype than the present imprecise and often misleading classification schemes. 

The challenge of HIV-1 subtype diversity.

The implications of subtype diversity in HIV-1 for possible differential rates of disease progression, responses to antiretroviral therapy (including the development of resistance), and vaccine development are discussed.

Host genetic influences on HIV-1 pathogenesis.

  • N. Michael
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    Current opinion in immunology
  • 1999

Clinical significance of HIV-1 coreceptor usage

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Genotypic analysis of HIV-1 coreceptor usage

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Biology of HIV-1 in women and men.

  • H. BurgerB. Weiser
  • Biology, Medicine
    Obstetrics and gynecology clinics of North America
  • 1997

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In this chapter, methods to determine the co-receptor usage of HIV-1 variants are described and phenotypically classified Viral isolates can be phenotypesically classified based on the co,receptor they utilize to infect target cells.

Point Mutations Associated with HIV-1 Drug Resistance, Evasion of the Immune Response and AIDS Pathogenesis

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It is shown that a mutant allele of CCR-5 is present at a high frequency in caucasian populations, but is absent in black populations from Western and Central Africa and Japanese populations, and a 32-base-pair deletion within the coding region results in a frame shift, and generates a non-functional receptor that does not support membrane fusion or infection by macrophage- and dual-tropic HIV-1 strains.

CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia

The CCR3 ligand, eotaxin, and an anti-CCR3 antibody inhibited HIV-1 infection of microglia, as did MIP-1β, which is a CCR5 ligand that promotes efficient infection of the CNS by HIV- 1.