A new classification for HIV-1

  title={A new classification for HIV-1},
  author={E. Berger and R. Doms and E. Fenyö and B. Korber and D. Littman and J. Moore and Q. Sattentau and H. Schuitemaker and J. Sodroski and R. Weiss},
The phenotype of HIV-1 isolates is defined by the cells in which they replicate in vitro, but these phenotypes can change in vivo with profound implications for viral transmission, pathogenesis and disease progression. Here we propose a new classification system based on co-receptor use, providing a more accurate description of viral phenotype than the present imprecise and often misleading classification schemes. 
869 Citations

Topics from this paper

The challenge of HIV-1 subtype diversity.
  • 526
Host genetic influences on HIV-1 pathogenesis.
  • N. Michael
  • Biology, Medicine
  • Current opinion in immunology
  • 1999
  • 119
Clinical significance of HIV-1 coreceptor usage
  • 91
  • PDF
Genotypic tropism testing: evidence-based or leap of faith?
  • 27
Coreceptor Usage and Biological Phenotypes of HIV-1 Isolates
  • 8
HIV: from molecular recognition to tissue pathogenesis
  • 11
Biology of HIV-1 in women and men.
  • 4
On HIV diversity.
  • 49
Genotypic analysis of HIV-1 coreceptor usage
  • 2
  • PDF
Determination of HIV-1 co-receptor usage.
  • 1