A new class of uracil-DNA glycosylases related to human thymine-DNA glycosylase

@article{Gallinari1996ANC,
  title={A new class of uracil-DNA glycosylases related to human thymine-DNA glycosylase},
  author={P. Gallinari and J. Jiricny},
  journal={Nature},
  year={1996},
  volume={383},
  pages={735-738}
}
  • P. Gallinari, J. Jiricny
  • Published 1996
  • Biology, Medicine
  • Nature
  • MISPAIRS in DNA of guanine with uracil and thymine can arise as a result of deamination of cytosine and 5-methylcytosine, respectively. In humans such mispairs are removed by thymine-DNA glycosylase (TDG)1–3. By deleting the carboxy and amino termini of this enzyme we have identified a core region capable of processing G/U but not G/T mispairs. We have further identified two bacterial proteins with strong sequence homology to this core and shown that the homologue from Escherichia coli (dsUDG… CONTINUE READING
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