A new class of uracil-DNA glycosylases related to human thymine-DNA glycosylase
@article{Gallinari1996ANC, title={A new class of uracil-DNA glycosylases related to human thymine-DNA glycosylase}, author={P. Gallinari and J. Jiricny}, journal={Nature}, year={1996}, volume={383}, pages={735-738} }
MISPAIRS in DNA of guanine with uracil and thymine can arise as a result of deamination of cytosine and 5-methylcytosine, respectively. In humans such mispairs are removed by thymine-DNA glycosylase (TDG)1–3. By deleting the carboxy and amino termini of this enzyme we have identified a core region capable of processing G/U but not G/T mispairs. We have further identified two bacterial proteins with strong sequence homology to this core and shown that the homologue from Escherichia coli (dsUDG… CONTINUE READING
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