A new class of irreversible muscarinic antagonists: beta-haloethylamine furoates.

@article{Rosen1976ANC,
  title={A new class of irreversible muscarinic antagonists: beta-haloethylamine furoates.},
  author={Gerald Rosen and Elmer J. Rauckman},
  journal={The Journal of pharmacy and pharmacology},
  year={1976},
  volume={28 9},
  pages={700-2}
}
The synthesis of a class of ultra-long acting muscarinic antagonists is described. Furthermore, it is noted that the stability of the, in situ, aziridinium ion is sufficiently great so that these agents can be used to study the effect of temperature upon the conformation of the muscarinic cholinoceptor. The inactivation kinetics of these receptors as well… CONTINUE READING