A new class of glutathione S-transferase from the hepatopancreas of the red sea bream Pagrus major.

@article{Konishi2005ANC,
  title={A new class of glutathione S-transferase from the hepatopancreas of the red sea bream Pagrus major.},
  author={Takafumi Konishi and Keitaro Kato and Toshiyoshi Araki and Kentaro Shiraki and Masahiro Takagi and Yutaka Tamaru},
  journal={The Biochemical journal},
  year={2005},
  volume={388 Pt 1},
  pages={299-307}
}
To elucidate drug deposition and metabolism in cultured marine fishes, in a previous study we isolated and purified the GSTs (glutathione S-transferases) from the hepatopancreas of the red sea bream Pagrus major that contained 25 and 28 kDa GST subunits. The 25 kDa GST subunits encoded by two genes (GSTA1 and GSTA2) have been identified as Alpha-class GSTs. In the present study, we performed the molecular cloning and characterization of the GSTR1 gene encoding the 28 kDa GST subunit from the Pa… CONTINUE READING