A new class of GABA agonist

@article{KrogsgaardLarsen1977ANC,
  title={A new class of GABA agonist},
  author={Povl Krogsgaard-Larsen and Graham A. R. Johnston and David Lodge and David R. Curtis},
  journal={Nature},
  year={1977},
  volume={268},
  pages={53-55}
}
COMPOUNDS which mimic the activity of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) on postsynaptic receptors are of particular pharmacological interest as possible therapeutic agents in human neurological disorders and as molecular probes with which to study different types of GABA receptors. The GABA molecule has considerable flexibility with free rotation around all three carbon–carbon bonds as indicated in Fig. 1. This conformational mobility is reduced in GABA analogues such… CONTINUE READING

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