A new class of COX-2 inhibitor, rutaecarpine from Evodia rutaecarpa

  title={A new class of COX-2 inhibitor, rutaecarpine from Evodia rutaecarpa},
  author={Tae Chul Moon and Makoto Murakami and Ichiro Kudo and Kun Ho Son and H. P. Kim and S. S. Kang and H. W. Chang},
  journal={Inflammation Research},
Abstract.Objective and Design: We investigated the effect of a new class of COX-2 inhibitor, rutaecarpine, on the production of PGD2 in bone marrow derived mast cells (BMMC) and PGE2 in COX-2 transfected HEK293 cells. Inflammation was induced by γ-carrageenan in male Splague-Dawley (SD) rats.¶Material: Rutaecarpine (8,13-Dihydroindolo[2',3':3,4]pyridol[2,1-b]quinazolin-5(7H)-one) was isolated from the fruits of Evodia rutaecarpa. BMMC were cultured with WEHI-3 conditioned medium. c-Kit ligand… 
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Update on clinical developments with celecoxib, a new specific COX-2 inhibitor: what can we expect?
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Functional Coupling Between Various Phospholipase A2s and Cyclooxygenases in Immediate and Delayed Prostanoid Biosynthetic Pathways*
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cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase.
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