A new chromogranin A-dependent angiogenic switch activated by thrombin.

@article{Crippa2013ANC,
  title={A new chromogranin A-dependent angiogenic switch activated by thrombin.},
  author={Luca Crippa and Mimma Bianco and Barbara Colombo and Anna Maria Gasparri and Elisabetta Ferrero and Yoke Peng Loh and Flavio Curnis and Angelo Corti},
  journal={Blood},
  year={2013},
  volume={121 2},
  pages={392-402}
}
Angiogenesis, the formation of blood vessels from pre-existing vasculature, is regulated by a complex interplay of anti and proangiogenic factors. We found that physiologic levels of circulating chromogranin A (CgA), a protein secreted by the neuroendocrine system, can inhibit angiogenesis in various in vitro and in vivo experimental models. Structure-activity studies showed that a functional anti-angiogenic site is located in the C-terminal region, whereas a latent anti-angiogenic site… CONTINUE READING
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