A new chromogranin A-dependent angiogenic switch activated by thrombin.

  title={A new chromogranin A-dependent angiogenic switch activated by thrombin.},
  author={Luca Crippa and Mimma Bianco and Barbara Colombo and Anna Maria Gasparri and Elisabetta Ferrero and Yoke Peng Loh and Flavio Curnis and Angelo Corti},
  volume={121 2},
Angiogenesis, the formation of blood vessels from pre-existing vasculature, is regulated by a complex interplay of anti and proangiogenic factors. We found that physiologic levels of circulating chromogranin A (CgA), a protein secreted by the neuroendocrine system, can inhibit angiogenesis in various in vitro and in vivo experimental models. Structure-activity studies showed that a functional anti-angiogenic site is located in the C-terminal region, whereas a latent anti-angiogenic site… CONTINUE READING
Highly Cited
This paper has 42 citations. REVIEW CITATIONS
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
23 Citations
48 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 23 extracted citations


Publications referenced by this paper.
Showing 1-10 of 48 references

Similar Papers

Loading similar papers…