A new chemical tool (C0036E08) supports the role of adenosine A(2B) receptors in mediating human mast cell activation.

@article{Buceta2008ANC,
  title={A new chemical tool (C0036E08) supports the role of adenosine A(2B) receptors in mediating human mast cell activation.},
  author={Montserrat Buceta and Eduardo Dominguez and Mari{\'a}n Castro and Jos{\'e} Brea and D. Gar{\'c}ıa {\'A}lvarez and Javier Barcala and Luis G Vald{\'e}s and Pedro {\'A}lvarez-Calder{\'o}n and Fernando Dom{\'i}nguez and Bernat Vidal and Jos{\'e} Luis D{\'i}az and Montse Miralpeix and Jorge Beleta and Mar{\'i}a Isabel Cadavid and Mar{\'i}a I. Loza},
  journal={Biochemical pharmacology},
  year={2008},
  volume={76 7},
  pages={912-21}
}
Asthma is a chronic inflammatory disease of the airways that involves many cell types, amongst which mast cells are known to be important. Adenosine, a potent bronchoconstricting agent, exerts its ability to modulate adenosine receptors of mast cells thereby potentiating derived mediator release, histamine being one of the first mediators to be released. The heterogeneity of sources of mast cells and the lack of highly potent ligands selective for the different adenosine receptor subtypes have… CONTINUE READING
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Immunological characterization of A2B adenosine receptors in human mast cells

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