A new bufadienolide with cytotoxic activity from the Chinese traditional drug Ch'an Su.

Abstract

AIM To study the bufadienolides in the Chinese traditional drug "Ch'an Su" and their cytotoxic activity. METHOD Various chromatographic techniques were used to isolate the constituents, and their structures were elucidated through physical and spectroscopic data. RESULTS Twenty compounds were isolated, and eighteen were evaluated in vitro for their cytotoxic activity against A-549 and K-562 cells. CONCLUSION Compound 1 (bufalin 3β-acrylic ester) was a new bufadienolide and exhibited the most potent activity against the two tumor cell lines with IC50 values of 7.16 and 6.83 nmol · L(-1). The relationships between structure and activity are discussed.

DOI: 10.1016/S1875-5364(14)60095-9

Cite this paper

@article{Xu2014ANB, title={A new bufadienolide with cytotoxic activity from the Chinese traditional drug Ch'an Su.}, author={Ran Xu and Hai-Qin Xie and Lu-Lu Deng and Jian Zhang and Fu-mei Yang and Jian-Hua Liu and Xiao-Jiang Hao and Yuan-hu Zhang}, journal={Chinese journal of natural medicines}, year={2014}, volume={12 8}, pages={623-7} }