A new assay system for evaluation of developmental immunotoxicity of chemical compounds using respiratory syncytial virus infection to offspring mice.

@article{Watanabe2008ANA,
  title={A new assay system for evaluation of developmental immunotoxicity of chemical compounds using respiratory syncytial virus infection to offspring mice.},
  author={Watanabe Watanabe and Tomomi Shimizu and Akane Hino and Masuyoshi Kurokawa},
  journal={Environmental toxicology and pharmacology},
  year={2008},
  volume={25 1},
  pages={
          69-74
        }
}
We evaluated the effect of 6-propyl-2-thiouracil (PTU), an anti-thyroid agent, on developmental immunity using respiratory syncytial virus (RSV) infection to offspring mice as a new risk assessment for brominated flame retardants (BFRs), because some BFRs are suspected of affecting the thyroid system. Pregnant mice were exposed to PTU in drinking water from gestation day 10 to weaning on postnatal day 21. Their offspring mice were infected intranasally with RSV. Exposure of 100ppm PTU… CONTINUE READING
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