A new approach to the classification of idiopathic inflammatory myopathy: myositis-specific autoantibodies define useful homogeneous patient groups.

@article{Love1991ANA,
  title={A new approach to the classification of idiopathic inflammatory myopathy: myositis-specific autoantibodies define useful homogeneous patient groups.},
  author={Laureen A Love and Richard L Leff and Douglas D. Fraser and Ira N. Targoff and Marinos C. Dalakas and Paul H. Plotz and Frederick W Miller},
  journal={Medicine},
  year={1991},
  volume={70 6},
  pages={360-74}
}
The IIM are a heterogeneous group of systemic rheumatic diseases which share the common features of chronic muscle weakness and mononuclear cell infiltrates in muscle. A number of classification schemes have been proposed for them, but none takes into consideration the marked immunologic, clinical, and genetic heterogeneity of the various clinical groups. We compared the usefulness of myositis-specific autoantibodies (anti-aminoacyl-tRNA synthetases, anti-SRP, anti-Mi-2 and anti-MAS) to the… CONTINUE READING
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