A new approach to protein fold recognition

  title={A new approach to protein fold recognition},
  author={D. T. Jones and W. R. Taylort and Janet M. Thornton},
THE prediction of protein tertiary structure from sequence using molecular energy calculations has not yet been successful; an alternative strategy of recognizing known motifs1 or folds2–4 in sequences looks more promising. We present here a new approach to fold recognition, whereby sequences are fitted directly onto the backbone coordinates of known protein structures. Our method for protein fold recognition involves automatic modelling of protein structures using a given sequence, and is… 

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