A new approach to optimal antibiotic dosage regimen by coupling pharmacokinetics and killing curve parameters.

@article{Garraffo1990ANA,
  title={A new approach to optimal antibiotic dosage regimen by coupling pharmacokinetics and killing curve parameters.},
  author={Rodolphe Garraffo and Pierre Dellamonica and Henri Bernard Drugeon and H. Etesse and Pauline Lapalus},
  journal={Methods and findings in experimental and clinical pharmacology},
  year={1990},
  volume={12 5},
  pages={325-32}
}
Antibiotic therapy is directed against bacteria responsible for infectious pathology which are able to resist treatment mainly when the dosage is misadapted. The choice of the initial dosage regimen actually takes into account toxicological, bacteriological and pharmacokinetic parameters. The determination of the classical bacteriological data is performed… CONTINUE READING