A new approach to generate a safe double-attenuated Plasmodium liver stage vaccine.

@article{Nagel2013ANA,
  title={A new approach to generate a safe double-attenuated Plasmodium liver stage vaccine.},
  author={Andreas Nagel and Monica Prado and Anna Heitmann and Susanne Tartz and Thomas Jacobs and Christina Deschermeier and Susanne Helm and Rebecca S Stanway and Volker T Heussler},
  journal={International journal for parasitology},
  year={2013},
  volume={43 6},
  pages={503-14}
}
Recently it has been shown in rodent malaria models that immunisation with genetically attenuated Plasmodium parasites can confer sterile protection against challenge with virulent parasites. For the mass production of live attenuated Plasmodium parasites for vaccination, safety is a prerequisite. Knockout of a single gene is not sufficient for such a strategy since the parasite can likely compensate for such a genetic modification and a single surviving parasite is sufficient to kill an… CONTINUE READING