A new approach to gene diagnosis of Duchenne/Becker muscular dystrophy--amplified fragment length polymorphisms.

Abstract

Four (CA)n repeats, located in introns 44, 45, 49 and 50 of the dystrophin gene, were evaluated in Chinese. These loci are highly polymorphic, with polymorphism information contents of 0.872, 0.772, 0.870 and 0.718, respectively. All four loci can be easily amplified and labelled using two duplex PCR reactions with alpha-32P-dCTP and can be detected by… (More)

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