A new approach to evaluating statistical significance of spectral identifications.

@article{Mohimani2013ANA,
  title={A new approach to evaluating statistical significance of spectral identifications.},
  author={Hosein Mohimani and Sangtae Kim and Pavel A. Pevzner},
  journal={Journal of proteome research},
  year={2013},
  volume={12 4},
  pages={1560-8}
}
While nonlinear peptide natural products such as Vancomycin and Daptomycin are among the most effective antibiotics, the computational techniques for sequencing such peptides are still in their infancy. Previous methods for sequencing peptide natural products are based on Nuclear Magnetic Resonance spectroscopy and require large amounts (milligrams) of purified materials. Recently, development of mass spectrometry-based methods has enabled accurate sequencing of nonlinear peptide natural… CONTINUE READING