A new approach to designing phase I-II cancer trials for cytotoxic chemotherapies.

Abstract

Recently, there has been much work on early phase cancer designs that incorporate both toxicity and efficacy data, called phase I-II designs because they combine elements of both phases. However, they do not explicitly address the phase II hypothesis test of H0 : p ≤ p0 , where p is the probability of efficacy at the estimated maximum tolerated dose η from… (More)
DOI: 10.1002/sim.6124

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Cite this paper

@article{Bartroff2014ANA, title={A new approach to designing phase I-II cancer trials for cytotoxic chemotherapies.}, author={Jay Bartroff and Tze Leung Lai and Balasubramanian Narasimhan}, journal={Statistics in medicine}, year={2014}, volume={33 16}, pages={2718-35} }