Multiscale pyramid image enhancement algorithm is an usual way to enhance the Digital Radiography (DR) images. However, the process of enhancement takes much of time because of the fine resolution of DR images. A new method of accelerating DR image enhancement based on Compute Unified Device Architecture (CUDA) is presented in this paper. This method completes a large amount of convolution operations in spatial domain involved in the multiscale pyramid image enhancement algorithm by using the Graphic Processing Unit (GPU). The experimental results show that the proposed method is very efficient for accelerating DR image enhancement.