A new approach for treatment of precancerous lesions with curcumin solid-lipid nanoparticle-loaded gels: in vitro and clinical evaluation.

@article{Hazzah2016ANA,
  title={A new approach for treatment of precancerous lesions with curcumin solid-lipid nanoparticle-loaded gels: in vitro and clinical evaluation.},
  author={Heba A. Hazzah and Ragwa Mohamed Farid and Maha M A Nasra and Mennatallah Zakaria and Yousria Gawish and Magda Abd Elsamea El-Massik and Ossama Y. Abdallah},
  journal={Drug delivery},
  year={2016},
  volume={23 4},
  pages={1409-19}
}
OBJECTIVE Preparation and characterization of curcumin solid-lipid nanoparticle (CurSLN)-loaded mucoadhesive gel for local treatment of oral precancerous lesions with low dose. METHODOLOGY The formulated CurSLNs were dispersed in a mucoadhesive gel matrix to be applied to the buccal mucosa. Conventional mucoadhesive gel using binary system was adopted. The prepared gels were evaluated for in vitro drug dialysis, ex vivo mucoadhesion test and ex vivo permeation study using chicken buccal… CONTINUE READING