A new approach for evaluating in vivo anti-leukemic activity using the SCE assay. An application on three newly synthesised anti-tumour steroidal esters.

@article{Karayianni2003ANA,
  title={A new approach for evaluating in vivo anti-leukemic activity using the SCE assay. An application on three newly synthesised anti-tumour steroidal esters.},
  author={Venetia Karayianni and E. Mioglou and Z. Iakovidou and D. Mourelatos and M. Fousteris and A. Koutsourea and E. Arsenou and S. Nikolaropoulos},
  journal={Mutation research},
  year={2003},
  volume={535 1},
  pages={
          79-86
        }
}
Three newly synthesised steroidal esteric derivatives of nitrogen mustard (compounds 1-3) were comparatively studied on a molar basis regarding their ability to induce sister chromatid exchanges (SCEs) in normal human lymphocytes in vitro and therapeutic effects on leukemia P388 bearing mice. Compounds 1 and 3 are modified steroidal esters of p-methyl-m-N,N-bis(2-chloroethyl)amino benzoic acid, and compound 2 is a modified steroidal ester of chlorambucil. All compounds induced statistically… Expand
20 Citations
Genotoxic, cytostatic, antineoplastic and apoptotic effects of newly synthesized antitumour steroidal esters.
  • 21
Preclinical studies on NSC290205 aza‐steroid alkylator activity in combination with adriamycin against lymphoid leukaemia
  • 10
Potentiation by caffeine of cytogenetic damage induced by steroidal derivatives in human lymphocytes in vitro.
  • 4
...
1
2
...

References

SHOWING 1-10 OF 12 REFERENCES
...
1
2
...