A new antiproliferative noscapine analogue: chemical synthesis and biological evaluation

@article{Ghaly2016ANA,
  title={A new antiproliferative noscapine analogue: chemical synthesis and biological evaluation},
  author={Peter E. Ghaly and Rabab M Abou El-Magd and Cassandra D M Churchill and Jack Adam Tuszynski and Frederick G. West},
  journal={Oncotarget},
  year={2016},
  volume={7},
  pages={40518 - 40530}
}
Noscapine, a naturally occurring opium alkaloid, is a widely used antitussive medication. Noscapine has low toxicity and recently it was also found to possess cytotoxic activity which led to the development of many noscapine analogues. In this paper we report on the synthesis and testing of a novel noscapine analogue. Cytotoxicity was assessed by MTT colorimetric assay using SKBR-3 and paclitaxel-resistant SKBR-3 breast cancer cell lines using different concentrations for both noscapine and the… 

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