A new antioxidative vitamin B6 analogue modulates pathophysiological cell proliferation and damage.

@article{Kesel1999ANA,
  title={A new antioxidative vitamin B6 analogue modulates pathophysiological cell proliferation and damage.},
  author={Andreas J. Kesel and I Sonnenbichler and Kurt Polborn and Lutz Guertler and Wolfgang E. F. Klinkert and Manuel Modolell and Andreas K. N{\"u}ssler and Walter Oberthuer},
  journal={Bioorganic & medicinal chemistry},
  year={1999},
  volume={7 2},
  pages={359-67}
}
The new large scale synthesis of the yellow colored vitamin B6 analogue 5'-O-phosphono-pyridoxylidenerhodanine (2) (B6PR) leads to oligohydrates of its monosodium salt (4). The light-red hemiheptadecahydrate (8 1/2 hydrate) (4a) was crystallized and its three-dimensional structure determined by X-ray crystallography. Special nucleotide and protein interaction properties together with scavenging antioxidative function are combined in this simple water-soluble vitamin B6 analogues B6PR. High (mM… CONTINUE READING