A new antifungal macrolide component, brasilinolide B, produced by Nocardia brasiliensis.

@article{Mikami2000ANA,
  title={A new antifungal macrolide component, brasilinolide B, produced by Nocardia brasiliensis.},
  author={Yuzuru Mikami and Hisayuki Komaki and Tamae Imai and Katsukiyo Yazawa and Akira Nemoto and Y Tanaka and U Gr{\"a}efe},
  journal={The Journal of antibiotics},
  year={2000},
  volume={53 1},
  pages={
          70-4
        }
}

Topics from this paper

Natural Products from Nocardia and Their Role in Pathogenicity
TLDR
A summary and discussion of Nocardia metabolites is presented, which may play a part in nocardiosis because of their cytotoxic, immunosuppressive and metal-chelating properties or otherwise vitally important functions.
Bioactive Compounds from Nocardia: Biosynthesis and Production
The infection caused by drug-resistant pathogens, such as cancer and cardiovascular diseases, are major causes of mortality in the world. Diverse bioactive molecules isolated from microbial or plant
Structure elucidation and biosynthetic gene cluster analysis of caniferolides A-D, new bioactive 36-membered macrolides from the marine-derived Streptomyces caniferus CA-271066.
TLDR
Genome sequencing followed by detailed bioinformatics analysis led to the identification of the corresponding biosynthetic gene cluster and allowed the prediction of the stereochemical outcome of their biosynthesis, confirming the relative stereochemistry of each stereocluster already determined by NMR and establishing their stereochemical relationship.
Bioactive molecules from Nocardia: diversity, bioactivities and biosynthesis
TLDR
The structural diversity and biological activities of compounds biosynthesized or biotransformed by Nocardia spp are summarized and the recent advances on biosynthetic mechanisms and genetic engineering approaches for enhanced production or structural/functional modification are presented.
Simple glycolipids of microbes: Chemistry, biological activity and metabolic engineering
TLDR
It is believed that experience of metabolic engineering of microbial lipids for biofuel production can now be harnessed towards a successful synthesis of microbial GLs for biomedical and other applications.
PM100117 and PM100118, new antitumor macrolides produced by a marine Streptomyces caniferus GUA-06-05-006A
TLDR
Two new bioactive polyhydroxyl macrolide lactones were isolated from the culture broth of the marine-derived Streptomyces caniferus GUA-06-05-006A, showing potent cytotoxicity against three human tumor cell lines and slight antifungal activity against Candida albicans ATCC10231.
Target-specific identification and characterization of the putative gene cluster for brasilinolide biosynthesis revealing the mechanistic insights and combinatorial synthetic utility of 2-deoxy-l-fucose biosynthetic enzymes.
TLDR
This study represents the first demonstration of TDP-2dF biosynthesis at the enzyme and molecular levels, and provides new hope for expanding the structural diversity of brasilinolides by combinatorial biosynthesis.
A comprehensive review of glycosylated bacterial natural products.
TLDR
This comprehensive analysis of 15 940 bacterial natural products revealed 3426 glycosides containing 344 distinct appended carbohydrates and highlights a range of unique opportunities for future biosynthetic study and glycodiversification efforts.
Surfactants tailored by the class Actinobacteria
TLDR
A comprehensive overview of the knowledge available on actinobacterial surfactants, the chemical structures that have been completely or partly elucidated, as well as the identity of the biosurfactant-producing strains is presented.
Synthetic studies toward the brasilinolides: controlled assembly of a protected C1-C38 polyol based on fragment union by complex aldol reactions.
TLDR
Asymmetric boron-mediated aldol reactions of chiral ketones with aldehydes proved effective both for controlled fragment assembly and coupling with predictable stereoinduction from the enolate component.
...
1
2
...

References

SHOWING 1-6 OF 6 REFERENCES
Brasilicardin A. A Novel Tricyclic Metabolite with Potent Immunosuppressive Activity from Actinomycete Nocardiabrasiliensis.
TLDR
Brasilicardin A is the first tricyclic compound consisting of an anti/syn/anti-perhydrophenanthrene skeleton with a rhamnose, an N-acetylglucosamine, and an amino acid moiety.
Brasilinolide A, a new macrolide antibiotic produced by Nocardia brasiliensis: producing strain, isolation and biological activity.
A new 32-membered macrolide antibiotic, brasilinolide A was isolated from the fermentation broth of Nocardia sp. IFM 0406. The producer was identified as Nocardia brasiliensis. The antibiotic was
Nocardicyclins A and B: new anthracycline antibiotics produced by Nocardia pseudobrasiliensis.
TLDR
Nocardicyclins A (1) and B (2), new anthracycline antibiotics have been isolated from the mycelial cake of Nocardia pseudobrasiliensis IFM 0624 (JCM 9894) and are active against Gram-positive bacteria including Mycobacterium spp.
Brasilinolide A, new immunosuppressive macrolide from actinomycete Nocardia brasiliensis
A new 32-membered macrolide, brasilinolide A (1), with potent immunosuppressive and antifungal activity was isolated from the cultured broth of the actinomycete Nocardia brasiliensis IFM 0406 and the
Brasiliquinones A-C, new cytotoxic benz [a] anthraquinones with an ethyl group at C-3 from actinomycete Nocardia brasiliensis
Three new cytotoxic benz[a]anthraquinones with an ethyl group at C-3, brasiliquinones A–C 1–3, have been isolated from the actinomycete Nocardia brasiliensis IFM 0089, and their structures elucidated
Demalonyl derivatives of guanidylfungin A and copiamycin: their synthesis and antifungal activity.
TLDR
Demalonylmethylguanidylfungin A became soluble in water and showed approximately eight-fold higher activity against fungi and Gram-positive bacteria than guanidyfordgin A, which also showed higher antifungal activity than copiamycin itself.