A new antifungal antibiotic, cystargin: fermentation, isolation, and characterization.

@article{Uramoto1988ANA,
  title={A new antifungal antibiotic, cystargin: fermentation, isolation, and characterization.},
  author={Masakazu Uramoto and Yumiko Itoh and Reiji Sekiguchi and Kazuo Shin‐ya and Hiroo Kusakabe and Kiyoshi Isono},
  journal={The Journal of antibiotics},
  year={1988},
  volume={41 12},
  pages={
          1763-8
        }
}
A new sulfur-containing peptide antifungal antibiotic, cystargin, was isolated from the fermentation broth of a new species of genus Kitasatosporia, designated as Kitasatosporia cystarginea. On acid hydrolysis, cystargin (C60H77N19O17S6) gave equimolar glycine, proline, aspartic acid and arginine. By performic acid oxidation, cysteic acid was detected after hydrolysis. It showed a growth inhibitory activity against various phytopathogenic fungi and inhibition of beta-1,3-glucan synthetase from… 
Cell wall active antifungal compounds produced by the marine fungus hypoxylon oceanicum LL-15G256. I. Taxonomy and fermentation.
TLDR
The cell wall targeted antifungal activity of Hypoxylon oceanicum LL-15G256 extracts resulted from the production of novel lipodepsipeptides and previously reported macrocyclic polylactones and seawater appeared to have an inhibitory effect on metabolite accumulation at lower fermentation temperatures.
Taxonomic studies on Kitasatosporia cystarginea sp. nov., which produces a new antifungal antibiotic cystargin.
TLDR
A significant properties of the species is the production of a new antifungal antibiotic, cystargin, which is characteristic in forming distinct spirals of spore chains.
Cell wall active antifungal compounds produced by the marine fungus Hypoxylon oceanicum LL-15G256. III. Biological properties of 15G256 gamma.
TLDR
Microscopic examination of treated fungi suggests that the compound acts by the inhibition of cell wall biosynthesis, but in vitro inhibition of Neurospora crassa glucan and chitin synthase were only observed at high drug concentrations suggesting that 15G256 gamma may act on a novel cell wall target.
Isolation and structure elucidation of satosporin A and B: new polyketides from Kitasatospora griseola.
Satosporins A and B, two novel glucosylated polyketides, were isolated from the actinomycete Kitasatospora griseola MF730-N6. The polyketides possess an unprecedented tricyclic ring system that was
Selection of Microbial Sources of Bioactive Compounds
Soon after penicillin was rediscovered as an antibiotic and named the “yellow magic medicine,” a new field of applied microbiology, i.e., that is, antibiotic screening, was introduced, especially by
Glucan Biosynthesis in Fungi and its Inhibition
TLDR
This chapter will focus on inhibitors of glucan synthesis; these can be grouped structurally as the papulacand in-type and the echinocandin-type compounds.
Cystargolides, 20S Proteasome Inhibitors Isolated from Kitasatospora cystarginea.
TLDR
Two novel β-lactone-containing natural products, cystargolides A and B, were isolated from the actinomycete Kitasatospora Cystarginea using a methodology associating liquid chromatography-high-resolution mass spectrometry (LC-HRMS) analysis and the statistical analysis tool principal component analysis (PCA).
Actinomycetes, Cyanobacteria and Algae
The actinomycetes or “ray fungi” are wide-spread, Gram-positive eubacteria belonging to the Actinomycetales, a large order that consists of approximately 60 genera. Genera of special interest include
Agroactive compounds of microbial origin.
TLDR
This review attempts to identify newer agroactive microbial metabolites with feasible activity or interesting action sites from those reported in recent years and discusses the possibility of future discovery of excellent microbial agrochemicals and the importance of efforts to promote positive public perception and public acceptance of pesticide chemicals.
Drug Discovery: Nature’s Approach
TLDR
Although the soil screen remains a major route for the discovery of new antifungal agents, intensive efforts have been undertaken to develop new methods for screening based upon mode of action, and mechanism-based tests may provide important alternatives to the more direct but capricious screen based on broth or agar dilution.
...
1
2
...

References

SHOWING 1-10 OF 14 REFERENCES
STUDIES ON ACULEACIN
TLDR
The antibiotic showed a potent activity against molds and yeasts, but exhibited no antibacterial activity, and has relatively low toxicity in mice.
Studies on aculeacin. I. Isolation and characterization of aculeacin A.
TLDR
The antibiotic showed a potent activity against molds and yeasts, but exhibited no antibacterial activity, and has relatively low toxicity in mice.
Structure and Biological Activity of Neopeptins A, B and C, Inhibitors of Fungal Cell Wall Glycan Synthesis
The antifungal antibiotics, neopetins A(1), B(2) and C(3), were found to be cyclic lipopeptides containing unusual amino acids, their structures being elucidated on the basis of chemical and
Taxonomic studies on Kitasatosporia cystarginea sp. nov., which produces a new antifungal antibiotic cystargin.
TLDR
A significant properties of the species is the production of a new antifungal antibiotic, cystargin, which is characteristic in forming distinct spirals of spore chains.
Sur la saramycétine (= X‐5079 C), polypeptide antibiotique de Streptomyces saraceticus. I. Premières données concernant sa structure
TLDR
Hydrolysis by strong hydrochloric acid degrades the antibiotic Saramycetin and produces acids containing heterocyclic sulphur, for which the name of saramycetic acids is proposed and which do not yield cystine by hydrolysis.
Stoffwechselprodukte von Mikroorganismen 143. Mitteilung. Echinocandin B, ein neuartiges Polypeptid‐Antibioticum aus Aspergillus nidulans var. echinulatus: Isolierung und Bausteine
From a strain of Aspergillus nidulans var. echinulatus, A 32204, echinocandin, a novel polypeptide antibiotic complex with high and specific anti-yeast activity was isolated. The main component,
Biosynthesis of the yeast cell wall. I. Preparation and properties of beta-(1 leads to 3)glucan synthetase.
TLDR
The synthesis of the major linkage found in yeast cell wall structural polysaccharides, glucosyl-beta-(1 leads to 3)-glucosyl, was studied with a membrane preparation from Saccharomyces cerevisiae and suggests localized and reversible activation of the enzyme during the cell cycle.
Inhibition of Microbial Cell Wall Synthesis by Lipopeptin A
TLDR
The inhibition of the formation of Glcnac-MurNAc-pentapeptide-p-p Lipid and UDP-GlcNAc is concluded to be the site of action, causing swelling in mycelia.
Structure and biological activity of neopeptins A, B and C, inhibitors offungal cell wall glucan synthesis
  • Agric. Biol. Chem
  • 1986
...
1
2
...