A new animal model of endogenous depression: a summary of present findings.

@article{Vogel1990ANA,
  title={A new animal model of endogenous depression: a summary of present findings.},
  author={Gerald W. Vogel and Darryl B Neill and Mary Hagler and D. Kors},
  journal={Neuroscience and biobehavioral reviews},
  year={1990},
  volume={14 1},
  pages={85-91}
}
In 1982 our laboratory proposed a new animal model of endogenous depression. The proposal was that in rats, neonatally administered clomipramine (CLI) will produce adult animals that model endogenous depression. We summarize here several tests of the validity of the model. Results were that after neonatal CLI, adult male rats showed behavioral abnormalities of the human disorder: decreased sexual, aggressive, and intracranial self-stimulation activities, as well as motor hyperactivity in a… CONTINUE READING
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