A new animal model for pulmonary hypertension based on the overexpression of a single gene, angiopoietin-1.

@article{Chu2004ANA,
  title={A new animal model for pulmonary hypertension based on the overexpression of a single gene, angiopoietin-1.},
  author={Danny Chu and Christopher Cyril Sullivan and Lingling Du and Augustine J Cho and Masakuni Kido and Paul L. Wolf and Matthew D Weitzman and Stuart W. Jamieson and Patricia A. Thistlethwaite},
  journal={The Annals of thoracic surgery},
  year={2004},
  volume={77 2},
  pages={449-56; discussion 456-7}
}
BACKGROUND Angiopoietin-1 gene expression in human pulmonary hypertensive lungs is directly proportional to increasing pulmonary vascular resistance. We hypothesized that targeted overexpresssion of angiopoietin-1 in the lung would cause persistent pulmonary hypertension in an animal model. METHODS We injected 2 x 10(10) genomic particles of adeno-associated virus-angiopoietin-1 (AAV-Ang-1) into the right ventricular outflow tract of 30 Fischer rats while using adeno-associated virus-lacZ… CONTINUE READING
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